TITLE CARD: Less seizures, more Ashley
SUPER: Please see Important Safety Information for BANZEL® (rufinamide) throughout and at the end of this video.
ADAM: Ashley is a beautiful 20-year-old young woman who was born with some developmental delays. She has dealt with medical problems her whole life but done it with so much grace and dignity—it's quite, quite impressive.
SUPER: Adam | Caregiver and parent of Ashley, diagnosed with LGS at 11 years old
ASHLEY: I’ve been working hard and trying my best.
ADAM: Yes you do, every day. Never quit.
ASHLEY: I never quit.
ADAM: There you go.
ADAM: One morning, all of a sudden, I heard this sickening thud hit the floor. My thought was she pulled on something and it fell over.
ADAM: I went running upstairs and found Ashley in the middle of what I now know is a grand mal, or tonic-clonic, seizure, just convulsing on the floor. And that was our first seizure.
TITLE CARD: LGS diagnosis
ADAM: Took her to the doctor and doctor said, well, she looks fine. Sometimes you can have this. Maybe it wasn't a seizure. It could've just been she was tired. So we went home. Couple hours later, she had another one. And then a couple hours later, another.
ADAM: They sent her in for an EEG. That was negative. I'm starting to question myself. And then, as we were leaving the lab, she had one. I'm, like, screaming, look, get every doctor. This is what we're seeing. And like, oh, yeah, that's seizure, and they admit her to the hospital.
ADAM: We started trying medications. It was probably about 4 and a half months later, when we were just not making any progress, that our neurologist had said, you know, I've seen very few of these cases, but this, I tell you, is Lennox-Gastaut.
ADAM: Ashley was 11 years old at the time.
ADAM: Which is a very unique case because often it's diagnosed a lot earlier in life. But she said with Ashley's developmental delays and other things, this was happening later.
TITLE CARD: Discovering BANZEL® (rufinamide) to treat LGS
SUPER: Please see Important Safety Information for BANZEL throughout and at the end of this video.
ADAM: When the doctor decided to prescribe the BANZEL, Ashley was on 3 other medications, and the doctor felt that this would be a good combo to use with her existing medications, as an add-on medication.
SUPER: BANZEL (rufinamide) is a prescription medication approved for adjunctive treatment of seizures associated with Lennox-Gastaut Syndrome (LGS) in pediatric patients 1 year of age and older, and in adults.
ADAM: The doctor, you know, wanted to go very, very slowly and carefully with it. There were side effects that she was concerned about. The 3 big ones were changes in her mood, muscle weakness/fatigue, and the big one she had was the drooling, but you know, that was about it.
SUPER: In studies, the most commonly observed (≥10%) side effects with BANZEL were headache, dizziness, feeling tired, sleepiness, and nausea.
SUPER: Patients with a history of Familial Short QT syndrome should not be treated with BANZEL. Talk to your healthcare provider if you are unsure if this affects you or your loved one. BANZEL has been shown to reduce the QT interval. Caution should be used when administering BANZEL with other drugs that shorten the QT interval.
ADAM: Once Ashley started taking the BANZEL it took a little time but we started to see that the frequency of the seizures started to slow down. That was the moment that I called the doctor and we were on the phone cheering because, you know, the numbers were starting to drop.
SUPER: In a clinical trial of 138 patients with LGS (ages 4-30) where BANZEL was added to their current therapy, BANZEL was shown to reduce the frequency of total seizures by 32.7% vs 11.7% reduction in the placebo group.
SUPER: Individual results may vary.
ADAM: I've thought about this many ways. And there is no one super cure for anything. But BANZEL has been effective for Ashley.
SUPER: All medications to treat seizures, including BANZEL, may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Call your healthcare provider right away if you or your loved one experiences new or worsening symptoms of depression, unusual changes in mood or behavior, thoughts or actions about suicide or self-harm, aggression, agitation, anger, anxiety, or irritability.
TITLE CARD: Loving less seizures with BANZEL
ADAM: I think our emotional journey since being diagnosed with LGS ’til now has been a roller-coaster through another dimension. Highs and lows. Nights where I, in moments of weakness, begged God to take her—just end her suffering. Breakdowns where I was screaming at the doctor to do surgery to cut my daughter's brain open and fix this darn problem.
ADAM: But also rewarding. Watching the strength that I've gained going through it, watching the incredible strength, bravery, and dignity that my daughter has gone through dealing with this. And that she still has such a high compassion for loving others, which is amazing because she has every right to be selfishly angry at the world, and she's not.
ADAM: As fragile as her body is, she is the strongest person I know. She gets up every day, smile on her face. And she gets the most out of the day that she can, more than I think a lot of us do.
ASHLEY: I love you with all my heart.
ADAM: I love you with all my heart.
END FRAME: Love less seizures
SUPER: Adam is a caregiver of a child with LGS and was compensated for his time in the creation of this video.
Please speak with your healthcare provider regarding your loved one’s treatment options. All medications should be discussed with a physician before starting treatment.
BANZEL (rufinamide) is a prescription medication approved for adjunctive treatment of seizures associated with Lennox-Gastaut Syndrome (LGS) in pediatric patients 1 year of age and older, and in adults.
Important Safety Information
- Patients with a history of Familial Short QT syndrome should not be treated with BANZEL. Talk to your healthcare provider if you are unsure if this affects you or your loved one. BANZEL has been shown to reduce the QT interval. Caution should be used when administering BANZEL with other drugs that shorten the QT interval.
- All medications to treat seizures, including BANZEL, may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Call your healthcare provider right away if you or your loved one experiences new or worsening symptoms of depression, unusual changes in mood or behavior, thoughts or actions about suicide or self-harm, aggression, agitation, anger, anxiety, or irritability.
- Use of BANZEL has been associated with side effects such as sleepiness or feeling tired, difficulty with coordination, dizziness, and problems with walking or movement.
- Do not drive, operate heavy machinery, or do other dangerous activities until you know how BANZEL affects you. BANZEL can slow your thinking and motor skills.
- Alcohol, in combination with BANZEL, may increase or worsen these side effects.
- Call your healthcare provider if you or your loved one experiences a rash. This can be a sign of a more serious condition, such as multi-organ hypersensitivity reaction.
- You or your loved one should take BANZEL only as prescribed. Do not stop taking BANZEL without first talking to your healthcare provider. Stopping BANZEL suddenly can cause serious problems.
- Tell your healthcare provider about all the medications you or your loved one takes, including prescription and non-prescription medications, vitamins, and herbal supplements. Using BANZEL with certain medications can affect each other, causing side effects.
- In studies, the most commonly observed (≥10%) side effects with BANZEL were headache, dizziness, feeling tired, sleepiness, and nausea.
Important Information for Women
- BANZEL may make hormonal contraceptives (birth control pills) less effective. Additional nonhormonal forms of birth control are recommended when using BANZEL.
- Healthcare providers should be informed if patients are pregnant or planning on becoming pregnant.
- Also, BANZEL is likely to be passed through breast milk to the baby and could cause serious side effects in the baby. A decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
- Patients who are pregnant are encouraged to enroll in the North American Antiepileptic Drug Pregnancy Registry. This can be done by calling the toll-free number 1-888-233-2334. Additional information about the registry can be found at www.aedpregnancyregistry.org.
There are risks associated with the use of BANZEL that you should know about. We encourage you to talk to your healthcare provider about these risks.
Please read the full Prescribing Information, and discuss it with your doctor or healthcare professional.
To report suspected adverse reactions, contact Eisai Inc. at 1-888-274-2378 or the FDA at 1-800-FDA-1088 or www.FDA.gov/medwatch.
The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare professional. All decisions regarding patient care must be made with a healthcare professional, considering the unique characteristics of the patient.