BANZEL® (rufinamide) OFFERS FLEXIBLE DOSING OPTIONS

Multiple dosing formulations

BANZEL offers 2 formulations for administration1

  • Tablets: 200 mg and 400 mg
  • Oral suspension: 40 mg/mL

Tablets can be administered whole, as half tablets, or crushed

  • Advise patients to take BANZEL with food
Bottle of BANZEL liquid dosing bottle with syringes. Image of 2 BANZEL pills—a 200 mg pill and a 400 mg pill.

Dose for children: 45 mg/kg/day or 3200 mg/day, whichever is less1

Sample titration schedules: Child 1 year and older*

Shows a sample BANZEL titration schedule for children 1 year and older. When titrating every other day, dose as follows: Day 1 (10 mg/kg/day); Day 3 (20 mg/kg/day); Day 5 (30 mg/kg/day); Day 7 (45 mg/kg/day).. Treatment should be initiated at a daily dose of approximately 10 mg/kg/day administered in 2 equally divided doses. The dose should be increased by approximately 10 mg/kg increments every other day to a target dose of 45 mg/kg/day or 3200 mg/day, whichever is less, administered in 2 equally divided doses. It is not known whether doses lower than the target doses are effective. Shows a sample BANZEL titration schedule for children 1 year and older. When titrating every other day, dose as follows: Day 1 (10 mg/kg/day); Day 3 (20 mg/kg/day); Day 5 (30 mg/kg/day); Day 7 (45 mg/kg/day).. Treatment should be initiated at a daily dose of approximately 10 mg/kg/day administered in 2 equally divided doses. The dose should be increased by approximately 10 mg/kg increments every other day to a target dose of 45 mg/kg/day or 3200 mg/day, whichever is less, administered in 2 equally divided doses. It is not known whether doses lower than the target doses are effective.
  • *Treatment should be initiated at a daily dose of approximately 10 mg/kg/day administered in 2 equally divided doses. The dose should be increased by approximately 10 mg/kg increments every other day to a target dose of 45 mg/kg/day or 3200 mg/day, whichever is less, administered in 2 equally divided doses.1
  • Divided into 2 equal doses.
  • It is not known whether doses lower than the target doses are effective.

In the pivotal trial, the target dose of approximately 45 mg/kg/day was achieved in 88% of BANZEL-treated patients.1

  • The majority of these patients reached the target dose within 7 days, with the remaining patients achieving the target dose within 14 days

Maximum dose for adults: 3200 mg/day1

Sample titration schedules: Adult*

Shows a sample BANZEL titration schedule for adults. When given in 400 mg increments every other day, the following titration schedule should be followed: Day 1 (400 mg/day); Day 3 (800 mg/day); Day 5 (1200 mg/day); Day 7 (1600 mg/day); Day 9 (2000 mg/day); Day 11 (2400 mg/day); Day 13 (2800 mg/day); Day 15 (3200 mg/day). When following 800 mg increments every other day, dose as follows:  Day 1 (800 mg/day); Day 3 (1600 mg/day); Day 5 (2400 mg/day); Day  7 (3200 mg/day).  Treatment should be initiated at a daily dose of 400-800 mg/day administered in 2 equally divided doses. The dose should be increased by 400-800 mg every other day until a maximum dose of 3200 mg/day, administered in 2 equally divided doses, is reached. It is not known whether doses lower than 3200 mg/day are effective. Shows a sample BANZEL titration schedule for adults. When given in 400 mg increments every other day, the following titration schedule should be followed: Day 1 (400 mg/day); Day 3 (800 mg/day); Day 5 (1200 mg/day); Day 7 (1600 mg/day); Day 9 (2000 mg/day); Day 11 (2400 mg/day); Day 13 (2800 mg/day); Day 15 (3200 mg/day). When following 800 mg increments every other day, dose as follows:  Day 1 (800 mg/day); Day 3 (1600 mg/day); Day 5 (2400 mg/day); Day  7 (3200 mg/day).  Treatment should be initiated at a daily dose of 400-800 mg/day administered in 2 equally divided doses. The dose should be increased by 400-800 mg every other day until a maximum dose of 3200 mg/day, administered in 2 equally divided doses, is reached. It is not known whether doses lower than 3200 mg/day are effective.
  • *Treatment should be initiated at a daily dose of 400-800 mg/day administered in 2 equally divided doses.The dose should be increased by 400-800 mg every other day until a maximum dose of 3200 mg/day, administered in 2 equally divided doses, is reached.1
  • Divided into 2 equal doses.
  • It is not known whether doses lower than 3200 mg/day are effective.
  • The average daily dose during the maintenance period in the pivotal trial was 1665 mg/day (41 mg/kg/day)2
  • References: 1. BANZEL® (rufinamide) prescribing information, Eisai Inc.
    2. Data on file, Eisai Inc.