LGS facts

Lennox-Gastaut syndrome (LGS) is a rare and severe form of epilepsy. If your loved one has LGS, it’s important to learn as much as possible so you can help them get the right treatment and care.

Did you know?

LGS is found more often in boys than in girls1, 2
Some causes of LGS include issues with brain formation or head injury3
In 30-35% of LGS cases, no cause can be found3
As many as 10% of all childhood epilepsy cases are LGS4, 5
For most people with LGS, seizure types change as they get older6
By adulthood, about 50% to 75% of people with LGS no longer have the typical brain electroencephalogram (EEG) activity associated with LGS7

How do you know it’s LGS?

LGS has many features and can be hard to diagnose. Three signs to look for include: 

Several seizure types

Slowed intellectual ability

Distinct brain wave pattern

LGS may be missed, or misdiagnosed as another form of severe epilepsy, such as refractory or uncontrolled epilepsy.

Can LGS seizures change over time?

The features of LGS usually last, and may change through childhood into adulthood. And seizures associated with LGS can be hard to control. Normal development is rare, which can also be a challenge to a parent or caregiver. 

ALT

How do you treat LGS?

Most people who have LGS are given multiple drugs to control their seizures. These treatments are known as antiepileptic drugs (AEDs). BANZEL® (rufinamide) is a prescription add-on AED approved for treatment of multiple seizure types associated with LGS in children 1 year of age and older, and in adults.

It’s important to remember:

  • While many AEDs have similar side effects, it's important to note that each one may have unique side effects that differ from others
  • Work with your doctor to balance seizure control and how your loved one’s body tolerates the medicine
  • Some people whose seizures improve from one AED may lose their response to the AED(s) over time.
  • When finding the right AED, be sure to let your doctor know all the drugs (including vitamins and herbal supplements) the person with LGS is taking

What are some other ways to treat LGS?

There are a few other ways to help treat LGS, including:

The ketogenic diet

Vagus nerve stimulation (VNS)

Corpus callosotomy

How do I care for someone with LGS?

As a parent or caregiver of someone diagnosed with LGS, you need information. So it’s important to prepare yourself for every appointment and ask your treatment team the right questions. Think of the treatment team as your partner, and ask about the best treatment options.

References:

Indication

BANZEL (rufinamide) is a prescription medication approved for adjunctive treatment of seizures associated with Lennox-Gastaut Syndrome (LGS) in pediatric patients 1 year of age and older, and in adults.

Important Safety Information

  • Patients with a history of Familial Short QT syndrome should not be treated with BANZEL. Talk to your healthcare provider if you are unsure if this affects you or your loved one. BANZEL has been shown to reduce the QT interval. Caution should be used when administering BANZEL with other drugs that shorten the QT interval.

  • All medications to treat seizures, including BANZEL, may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Call your healthcare provider right away if you or your loved one experiences new or worsening symptoms of depression, unusual changes in mood or behavior, thoughts or actions about suicide or self-harm, aggression, agitation, anger, anxiety, or irritability.

  • Use of BANZEL has been associated with side effects such as sleepiness or feeling tired, difficulty with coordination, dizziness, and problems with walking or movement.

  • Do not drive, operate heavy machinery, or do other dangerous activities until you know how BANZEL affects you. BANZEL can slow your thinking and motor skills.

    • Alcohol, in combination with BANZEL, may increase or worsen these side effects.

  • Call your healthcare provider if you or your loved one experiences a rash. This can be a sign of a more serious condition, such as multi-organ hypersensitivity reaction.

  • You or your loved one should take BANZEL only as prescribed. Do not stop taking BANZEL without first talking to your healthcare provider. Stopping BANZEL suddenly can cause serious problems.

  • Tell your healthcare provider about all the medications you or your loved one takes, including prescription and non-prescription medications, vitamins, and herbal supplements. Using BANZEL with certain medications can affect each other, causing side effects.

  • In studies, the most commonly observed (≥10%) side effects with BANZEL were headache, dizziness, feeling tired, sleepiness, and nausea.

Important Information for Women

  • BANZEL may make hormonal contraceptives (birth control pills) less effective. Additional nonhormonal forms of birth control are recommended when using BANZEL.

  • Healthcare providers should be informed if patients are pregnant or planning on becoming pregnant.

  • Also, BANZEL is likely to be passed through breast milk to the baby and could cause serious side effects in the baby. A decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

  • Patients who are pregnant are encouraged to enroll in the North American Antiepileptic Drug Pregnancy Registry. This can be done by calling the toll-free number 1-888-233-2334. Additional information about the registry can be found at www.aedpregnancyregistry.org.

There are risks associated with the use of BANZEL that you should know about. We encourage you to talk to your healthcare provider about these risks.

Please read the full Prescribing Information and discuss it with your doctor or healthcare professional.

To report suspected adverse reactions, contact Eisai Inc. at 1-888-274-2378 or the FDA at 1-800-FDA-1088 or www.FDA.gov/medwatch.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare professional. All decisions regarding patient care must be made with a healthcare professional, considering the unique characteristics of the patient.

This Web site contains information relating to various medical conditions and treatment. Such information is provided for educational purposes only and is not meant to be a substitute for the advice of a physician or other healthcare professionals. You should not use this information for diagnosing a health problem or disease. In order for you to make intelligent healthcare decisions, you should always consult with a physician or other healthcare provider for your, or your loved one’s, personal medical needs. All quotes included in this Web site represent the individual experience of some doctors, some patients, and their caregivers. Individual responses to treatment may vary.

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