Types of seizures

Your child means the world to you. And it would mean so much for them to have fewer seizures. Learn about seizures and epilepsy below, as well as the broad range of Lennox-Gastaut syndrome (LGS) seizures that BANZEL treats.

What is a seizure?

A seizure is a sudden, abnormal episode of electrical activity in the brain. It can cause uncontrolled movement or behavior.

Remember, as people with Lennox-Gastaut syndrome (LGS) grow older, seizure types may change over time.

What is epilepsy?

Epilepsy is a condition in which seizures occur repeatedly. There is no cure for epilepsy, but medicines may be used to help control it. Often, the cause of epilepsy is unknown.

What is refractory epilepsy?

Refractory epilepsy refers to uncontrolled seizures, despite taking medicine to treat them. You may also hear this called “uncontrolled,” “intractable,” or “drug-resistant” epilepsy.

What is LGS?

LGS is a rare and severe form of epilepsy that usually develops between the ages of 1 and 7. However, the diagnosis can be missed and people can be diagnosed with LGS as an adult.

Seizure types associated with LGS

Having multiple seizure types is a characteristic feature of LGS. Find out more about each of the following seizure types.

Tonic

Tonic seizures cause muscles to tighten for a few seconds, up to a minute. Eyes may roll back and pupils might dilate. Breathing may stop briefly and the heart rate can increase. Tonic seizures mostly happen during sleep but if experienced while awake, the person may fall. Tonic (along with atonic) seizures are the most common seizures associated with LGS.

Atonic

Atonic seizures may cause a person’s head or body to go limp. These might result in falls that are often called "drop attacks" or "drop seizures."

Clonic

Clonic seizures cause a pattern of jerking movements. These seizure types usually happen with other seizure types. Clonic seizures are not frequent in people with LGS.

Tonic-clonic

Tonic-clonic seizures can begin with stiffening limbs, which is the tonic phase. Then the limbs may jerk, which is the clonic phase.

Atypical absence

Atypical absence seizures include staring spells that last about 5 to 30 seconds. Spells start and stop gradually. They may include breaks in activity and a lack of response. Eye blinking and a brief lack of awareness may also occur.

Myoclonic

Myoclonic seizures cause muscles to jerk suddenly. They usually happen the same way on both sides of the body.

Partial

Partial seizures, also called focal seizures, start in specific areas in one side of the brain. Sometimes, consciousness may be affected.

"What keeps me going when things get tough is my child. If he’s not going to give up, why would I?"

Meet Dylan, living with LGS—and his mom, Kayleigh.

Indication

BANZEL (rufinamide) is a prescription medication approved for adjunctive treatment of seizures associated with Lennox-Gastaut Syndrome (LGS) in pediatric patients 1 year of age and older, and in adults.

Important Safety Information

  • Patients with a history of Familial Short QT syndrome should not be treated with BANZEL. Talk to your healthcare provider if you are unsure if this affects you or your loved one. BANZEL has been shown to reduce the QT interval. Caution should be used when administering BANZEL with other drugs that shorten the QT interval.

  • All medications to treat seizures, including BANZEL, may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Call your healthcare provider right away if you or your loved one experiences new or worsening symptoms of depression, unusual changes in mood or behavior, thoughts or actions about suicide or self-harm, aggression, agitation, anger, anxiety, or irritability.

  • Use of BANZEL has been associated with side effects such as sleepiness or feeling tired, difficulty with coordination, dizziness, and problems with walking or movement.

  • Do not drive, operate heavy machinery, or do other dangerous activities until you know how BANZEL affects you. BANZEL can slow your thinking and motor skills.

    • Alcohol, in combination with BANZEL, may increase or worsen these side effects.

  • Call your healthcare provider if you or your loved one experiences a rash. This can be a sign of a more serious condition, such as multi-organ hypersensitivity reaction.

  • You or your loved one should take BANZEL only as prescribed. Do not stop taking BANZEL without first talking to your healthcare provider. Stopping BANZEL suddenly can cause serious problems.

  • Tell your healthcare provider about all the medications you or your loved one takes, including prescription and non-prescription medications, vitamins, and herbal supplements. Using BANZEL with certain medications can affect each other, causing side effects.

  • In studies, the most commonly observed (≥10%) side effects with BANZEL were headache, dizziness, feeling tired, sleepiness, and nausea.

Important Information for Women

  • BANZEL may make hormonal contraceptives (birth control pills) less effective. Additional nonhormonal forms of birth control are recommended when using BANZEL.

  • Healthcare providers should be informed if patients are pregnant or planning on becoming pregnant.

  • Also, BANZEL is likely to be passed through breast milk to the baby and could cause serious side effects in the baby. A decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

  • Patients who are pregnant are encouraged to enroll in the North American Antiepileptic Drug Pregnancy Registry. This can be done by calling the toll-free number 1-888-233-2334. Additional information about the registry can be found at www.aedpregnancyregistry.org.

There are risks associated with the use of BANZEL that you should know about. We encourage you to talk to your healthcare provider about these risks.

Please read the full Prescribing Information and discuss it with your doctor or healthcare professional.

To report suspected adverse reactions, contact Eisai Inc. at 1-888-274-2378 or the FDA at 1-800-FDA-1088 or www.FDA.gov/medwatch.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare professional. All decisions regarding patient care must be made with a healthcare professional, considering the unique characteristics of the patient.

This Web site contains information relating to various medical conditions and treatment. Such information is provided for educational purposes only and is not meant to be a substitute for the advice of a physician or other healthcare professionals. You should not use this information for diagnosing a health problem or disease. In order for you to make intelligent healthcare decisions, you should always consult with a physician or other healthcare provider for your, or your loved one’s, personal medical needs. All quotes included in this Web site represent the individual experience of some doctors, some patients, and their caregivers. Individual responses to treatment may vary.

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